"ATP7A and ATP7B Copper Transport Gene Mutations in the Mastiff Breed" Study

The MCOA Health Committee is partnering with UC Davis to offer discounted DNA testing for ATP7A and ATP7B gene mutations.

The ATP7A and ATP7B genes are involved with the transport and regulation of copper within a dog’s body. Mutations of the ATP7B gene can cause copper overload within the liver and the brain.

The ATP7A and ATP7B gene mutations have been found within our breed. We don’t know if there is any clinical significance for Mastiffs who carry one or more copies of either gene mutation. At this point, we do not know if these gene mutations have an effect on Mastiff health.

"DNA sample collection to study dog breed differences in drug response" Study

Has your Mastiff had an adverse reaction to anesthesia/sedation or post operative bleeding? If so, researchers at College of Veterinary Medicine, Washington State University could use your DNA

What is the purpose of this study?

  • The purpose of this study is to identify genetic causes of adverse drug reactions that are thought to occur more frequently in certain dog breeds
  • This study can provide valuable information to help prevent adverse drug reactions by identifying genes that may make certain patients more susceptible to adverse drug reactions
  • The long term goal of the study is to prevent adverse drug reactions in dogs by using genetic testing to identify patients at risk for adverse drug reactions. These patients could then be treated with a different drug dose or a different type of drug
For more information or to request DNA swabs, please contact Mary DeLisa (divinemastiffs@gmail.com).

AKC Donor Advised Fund

The AKC Donor Advised Fund (DAF) supports canine health research. The Mastiff Coub of America Health Committee has chosen to contribute to the following grant and/or research program areas:

Studies & Trials

Updated: 05/18/2025